The Effect Of Empagliflozin ( Jardiance ), An Inhibitor Of...

Objective To evaluate the effects of empagliflozin(JARDIANCE), an inhibitor of sodium–glucose cotransporter 2, in addition to standard care, on cardiovascular morbidity and mortality in patients with type 2 diabetes at high cardiovascular risk. Background According to the International Diabetes Federation (IDF), more than 371 million people across the globe have diabetes and this figure is predicted to rise to over 550 million by 2030. Type 2 diabetes occurs when the hormone insulin is not used effectively by the cells in your body. Insulin is needed for cells to take in glucose from the bloodstream and convert it into energy. Ineffective use of insulin results in the body becoming resistant to normal levels of insulin. When the body becomes resistant, in advanced stages, insulin secreted cells in the pancreas becomes damaged, and eventually requires exogenous insulin to maintain sufficient levels. First line treatment for diabetes mellitus is currently a combination of diet and lifestyle modifications as well as oral glycemic agents. Therapy usually starts with Metformin, but based on doctor preferences, individual patient parameters, as well as clinical trial conclusions, there are many drugs on the market that can be used alternatively, such as sulfonylureas, which are seen very often. Monitoring parameters usually include self blood glucose testing, by using glucometers as seen over the counter in pharmacies. For patients with advanced stages ofShow MoreRelatedDiabetes Is The Most Common Form Of Diabetes849 Words   |  4 PagesType 2 Diabetes is the most common form of diabetes in adults. It accounts for approximately 90%-95% of diagnosed diabetes in adults in the United States (cdc.gov, n.d.). Newly diagnose cases of diabetes tripled from 1980-2011 in the United States. It is a costly and deadly disease. Because there are many comorbidities and complications associa ted with uncontrolled diabetes, it is essential to treat diabetes effectively. Clinicians deal with this ongoing problem on a daily basis. Therefore,